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| University Name [State] | Year | Type | Address |
| Black Hills State University [SD] | 1883 | Public institution | 1200 University Street, Unit 9500 Spearfish, SD 57799-9500 |
| Dakota State University [SD] | 1881 | Public institution | 820 N. Washington Avenue Madison, SD 57042 |
| Dakota Wesleyan University [SD] | 1885 | Private institution | 1200 W. University Avenue Mitchell, SD 57301 |
| Mount Marty College [SD] | 1936 | Private institution | 1105 W. Eighth Street Yankton, SD 57078 |
| National American University [SD] | 0 | Private institution | 321 Kansas City Street Rapid City, SD 57701 |
| Northern State University [SD] | 1901 | Public institution | 1200 S. Jay Street Aberdeen, SD 57401-7198 |
| Oglala Lakota College [SD] | 0 | P.O. Box 490 Kyle, SD 57752 |
|
| Presentation College [SD] | 0 | 1500 North Main Street Aberdeen, SD 57401 |
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| Si Tanka University [SD] | 0 | Eagle Butte, SD |
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| Sinte Gleska University [SD] | 0 | Spotted Tail Drive Rosebud, SD 57570 |
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| South Dakota School of Mines and Technology [SD] | 1885 | Public institution | 501 E. St. Joseph Street Rapid City, SD 57701 |
| South Dakota State University [SD] | 1881 | Public institution | Box 2201 Brookings, SD 57007 |
| University of Sioux Falls [SD] | 1883 | Private institution | 1101 W. 22nd Street Sioux Falls, SD 57105 |
| University of South Dakota [SD] | 1862 | Public institution | 414 E. Clark Street Vermillion, SD 57069 |